Manchester City could be without new signing Nico Gonzalez, who suffered an injury in their FA Cup match at the weekend. He joins Oscar Bobb, Nathan Ake, Jeremy Doku, and Ederson on the doubtful list, while midfield anchor Rodri remains sidelined with a long-term injury. However, Kevin De Bruyne is expected to return to the starting lineup, aiming to add to his impressive record against Real Madrid.

Real Madrid arrive in Manchester with defensive concerns, as Lucas Vazquez, Antonio Rudiger, Dani Carvajal, Eder Militao, and David Alaba are all unavailable. This could force Aurelien Tchouameni to deputize in central defense alongside young Raul Asencio. Several key players, including Jude Bellingham and Luka Modric, are also at risk of suspension if they receive a booking. Despite these issues, Carlo Ancelotti is expected to field a strong attacking lineup featuring Kylian Mbappe and Vinicius Junior.

Manchester City’s home form and attacking firepower make them favorites, but their shaky defense and Real Madrid’s never-say-die attitude in Europe could make for an even contest. With the visitors struggling defensively but boasting elite attacking options, an entertaining first leg is likely. Expect goals on both sides, with a 2-2 draw leaving the tie finely balanced ahead of the second leg in Madrid.