Inter are reeling from the loss of talisman Lautaro Martinez, who suffered a hamstring injury in the first leg. Simone Inzaghi must choose between Mehdi Taremi and Marko Arnautovic to partner Marcus Thuram up front. Benjamin Pavard is also sidelined, but Hakan Calhanoglu returns to marshal the midfield after suspension. Denzel Dumfries, who scored twice in the first leg, will start once more alongside established names like Mkhitaryan and Sommer.
Barcelona, meanwhile, are boosted by the return of Marc-André ter Stegen and could have Robert Lewandowski and Alejandro Balde back on the bench. Jules Koundé remains out, meaning Flick must again reshuffle his backline. Teen sensation Lamine Yamal, fresh off his wondergoal in the first leg, will be central to Barca's attacking hopes, flanked by the electric Raphinha and supported by the creative Dani Olmo and Pedri.
Inter Milan 1-2 Barcelona
Goals are all but guaranteed given both teams' attacking intent and defensive vulnerabilities. While Inter are usually solid at home, injuries and recent form suggest cracks are beginning to show. Barcelona’s youthful exuberance and clinical edge, led by Yamal and Raphinha, could prove decisive as the Blaugrana edge through in another thriller.